Reference number: OPUSeJ 201302021106LMX
Title: Lung morphometry using hyperpolarized 129Xe apparent diffusion coefficient anisotropy in chronic obstructive pulmonary disease
Authors: Alexei Ouriadov 1, Adam Farag 1, Miranda Kirby 1,2, David G. McCormack 3, Grace Parraga 1,2,4, Giles E. Santyr 1,2,4,*
Abstract: Purpose: The goal of this work was to investigate lung morphological changes associated with chronic obstructive pulmonary disease (COPD) using hyperpolarized 129Xe diffusion-weighted MRI.
Methods: Hyperpolarized 129Xe MRI was performed at three different nonzero diffusion sensitizations (b-value = 12, 20, and 30 s/cm2) in the lungs of four subjects with COPD and four healthy volunteers. The image signal intensities were fit as a function of b-value to obtain anisotropic diffusion coefficient maps for all subjects. The image signal intensities were also fit to a morphological model allowing extraction of length scales associated with the terminal airways: external radius (R), internal radius (r), mean airspace chord length (Lm), and depth of alveolar sleeve (h).
Results: Longitudinal (DL) and transverse (DT) anisotropic diffusion coefficients were both significantly increased (both P= 0.004) in the COPD subjects (0.102 ± 0.02 cm2/s and 0.072 ± 0.02 cm2/s, respectively) compared with the healthy subjects (0.083 ± 0.011 cm2/s and 0.046 ± 0.017 cm2/s, respectively). Significant morphological differences were observed between the COPD subjects and healthy volunteers, specifically decreases in h (68 ± 36 µm vs. 95 ± 710 µm, respectively, P = 0.019) and increases in Lm (352 ± 57 µm vs. 253 ± 37 µm, respectively, P = 0.002) consistent with values obtained previously using hyperpolarized 3He MRI in similar subjects.
Conclusions: Diffusion-weighted hyperpolarized 129Xe MRI is a promising technique for mapping changes in human lung morphology and may be useful for early detection of emphysema associated with COPD.
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1 Imaging Research Laboratories, Robarts Research Institute, Western University, London, Ontario, Canada
2 Department of Medical Biophysics, Western University, London, Ontario, Canada
3 Department of Medicine, Western University, London, Ontario, Canada
4 Department of Medical Imaging, Western University, London, Ontario, Canada
*Correspondence to: Giles E. Santyr, Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, London, Ontario ON N6A 5K8, Canada. (E-mail: email@example.com)
Keywords: ADC; anisotropy; lung;morphometry; hyperpolarized; xenon-129
Subject: Medicine/ lung morphology
Bibliography: (alphabetical) N/A
Citation: Ouriadov, A et al, 2013, “Lung morphometry using hyperpolarized 129Xe apparent diffusion coefficient anisotropy in chronic obstructive pulmonary disease”, Magn Reson Med. Published online 28 JAN 2013, doi: 10.1002/mrm.24595 http://onlinelibrary.wiley.com/doi/10.1002/mrm.24595/abstract?deniedAccessCustomisedMessage=&userIsAuthenticated=false