Date: 2013-12-22
Reference number: OPUSeJ 201312061419LEP
Links: to published version: http://www.ncbi.nlm.nih.gov/pubmed/23968942
to pre-reviewed version: N/A
Title: Less education predicts anticholinesterase discontinuation in dementia patients
Authors: Saleh S, Kirk A, Morgan DG & Karunanayake C
Abstract: OBJECTIVE: We investigated patient socio-demographic, clinical and functional factors predicting cholinesterase inhibitor discontinuation by patients presenting to a memory clinic in Saskatoon, Saskatchewan. METHODS: Data collection began in March 2004 at the Rural and Remote Memory Clinic where family physicians referred their non-institutionalized patients. Neurological and neuropsychological assessment, patient and caregiver questionnaires provided the socio-demographic, clinical and functional variables. Univariate logistic regression analysis was used to examine possible associations between each independent variable and the binary outcome variable of treatment discontinuation. Multivariate logistic regression was used to determine predictors of cholinesterase inhibitor discontinuation within six months of drug initiation. RESULTS: Our sample consisted of the first 63 patients (60.3% female) for whom we prescribed a cholinesterase inhibitor. The mean age at clinic day was 74.56 years (SD=7.78). We found that years of formal education was the only variable significantly associated with cholinesterase inhibitor discontinuation by six months. The more years of formal education, the lower the rate of drug discontinuation by six months. CONCLUSIONS: Likelihood of cholinesterase inhibitor discontinuation by six months was predicted by fewer years of formal education.
Author bio: N/A
Sponsor editor: N/A
Affiliations/disclaimers/funding/acknowledgements: N/A
Keywords: N/A
Subject: Neurology/dementia
Language: English
Bibliography: (alphabetical) N/A
Citation: Saleh S, Kirk A, Morgan DG & Karunanayake C, “Less education predicts anticholinesterase discontinuation in dementia patients”, Can J Neurol Sci. 2013 Sep;40(5):684-90. http://www.ncbi.nlm.nih.gov/pubmed/23968942.
References: see Forum Academic citations forward: none