Immunopathogenesis of osteoarthritis – cover

Date: 2013-03-06

Reference number: OPUSeJ 201303061649IOA

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Title: Immunopathogenesis of osteoarthritis

Authors: Abdul Haseeb & Tariq M Haqqi

Abstract: Even though osteoarthritis (OA) is mainly considered as a degradative condition of the articular cartilage, there is increasing body of data demonstrating the involvement of all branches of the immune system. Genetic, metabolic or mechanical factors cause an initial injury to the cartilage resulting in release of several cartilage specific auto-antigens, which trigger the activation of immune response. Immune cells including T cells, B cells and macrophages infiltrate the joint tissues, cytokines and chemokines are released from different kinds of cells present in the joint, complement system is activated, and cartilage degrading factors such as matrix metalloproteinases (MMPs) and prostaglandin E (PGE) are released, resulting in further damage to the articular cartilage. There is considerable success in the treatment of rheumatoid arthritis using anti-cytokine therapies. In OA, however, these therapies did not show much effect, highlighting more complex nature of pathogenesis of OA. This needs the development of more novel approaches to treat OA, which may include therapies that act on multiple targets. Plant natural products have this kind of property and may be considered for future drug development efforts. Here we reviewed the studies implicating different components of the immune system in the pathogenesis of OA.

Author bio:  N/A

Sponsor editor:  N/A

Affiliations/disclaimers/funding/acknowledgements: Department of Anatomy & Neurobiology, Northeast Ohio Medical University, 4209 St. Rt. 44, P.O. Box 95, Rootstown, OH 44272, USA.Keywords:  N/A

Keywords:  osteoarthritis; T cells; B cells; complement system; cytokines; chemokines

Subject:  Medicine/ osteoarthritis

Language: English

Bibliography: (alphabetical) N/A

Citation: Haseeb, A, & T M Haqqi, 2012, “Immunopathogenesis of osteoarthritis”, Clinical immunology 146:3, 185-196. doi: 10.1016/j.clim.2012.12.011. Epub ahead of print

References: see Forum

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