Gait and cognition: a complementary approach to understanding brain function and the risk of falling – Forum

Date: 2013-02-09

Reference number: OPUSeJ 201302091813GCF

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Title: Gait and cognition: a complementary approach to understanding brain function and the risk of falling

Authors: Montero-Odasso, Manuel, Joe Verghese, Olivier Beauchet & Jeffrey M. Hausdorff

Moderator: N/A

Overview: N/A

Addendum: none

Erratum: none

Bibliography: (alphabetical) N/A


1. van Iersel MB, Hoefsloot W, Munneke M et al. Systematic review of quantitative clinical gait analysis in patients with dementia. Z Gerontol Geriatr 2004;37:27–32.

2. Tinetti ME, Speechley M, Ginter SF. Risk factors for falls among elderly persons living in the community. N Engl J Med 1988;319:1701–1707.

3. Morris JC, Rubin EH, Morris EJ et al. Senile dementia of the Alzheimer’s type: An important risk factor for serious falls. J Gerontol 1987;42:412–417.

4. Woollacott M, Shumway-Cook A. Attention and the control of posture and gait: A review of an emerging area of research. Gait Posture 2002;16:1–14.

5. Yogev-Seligmann G, Hausdorff JM, Giladi N. The role of executive function and attention in gait. Mov Disord 2008;23:329–342.

6. Rosano C, Brach J, Longstreth WT Jr et al. Quantitative measures of gait characteristics indicate prevalence of underlying subclinical structural brain abnormalities in high-functioning older adults. Neuroepidemiology 2006;26:52–60.

7. Herman T, Mirelman A, Giladi N et al. Executive control deficits as a prodrome to falls in healthy older adults: A prospective study linking thinking, walking, and falling. J Gerontol A Biol Sci Med Sci 2010;65A: 1086–1092.

8. Muir SW, Gopaul K, Montero Odasso MM. The role of cognitive impairment in fall risk among older adults: A systematic review and meta-analysis. Age Ageing 2012;41:299–308.

9. Buracchio T, Dodge HH, Howieson D et al. The trajectory of gait speed preceding mild cognitive impairment. Arch Neurol 2010;67:980–986.

10. Lopez OL, Jagust WJ, DeKosky ST et al. Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: Part 1. Arch Neurol 2003;60:1385–1389.

11. Petersen RC, Doody R, Kurz A et al. Current concepts in mild cognitive impairment. Arch Neurol 2001;58:1985–1992.

12. Liu-Ambrose TY, Ashe MC, Graf P et al. Increased risk of falling in older community-dwelling women with mild cognitive impairment. Phys Ther 2008;88:1482–1491.

13. Verghese J, Robbins M, Holtzer R et al. Gait dysfunction in mild cognitive impairment syndromes. J Am Geriatr Soc 2008;56:1244–1251.

14. Montero-Odasso M, Bergman H, Phillips NA et al. Dual-tasking and gait in people with mild cognitive impairment. The effect of working memory. BMC Geriatr 2009;9:41.

15. Hausdorff JM, Yogev G, Springer S et al. Walking is more like catching than tapping: Gait in the elderly as a complex cognitive task. Exp Brain Res 2005;164:541–548.

16. Lundin-Olsson L, Nyberg L, Gustafson Y. “Stops walking when talking” as a predictor of falls in elderly people. Lancet 1997;349:617.

17. Beauchet O, Annweiler C, Dubost V et al. Stops walking when talking: A predictor of falls in older adults? Eur J Neurol 2009;16:786–795.

18. Yamada M, Aoyama T, Arai H et al. Dual-task walk is a reliable predictor of falls in robust elderly adults. J Am Geriatr Soc 2011;59:163–164.

19. Sheridan PL, Solomont J, Kowall N et al. Influence of executive function on locomotor function: Divided attention increases gait variability in Alzheimer’s disease. J Am Geriatr Soc 2003;51:1633–1637.

20. Bootsma-van der Wiel A, Gussekloo J, Craen de AJ et al. Walking and talking as predictors of falls in the general population: The Leiden 85-plus Study. J Am Geriatr Soc 2003;51:1466–1471.

21. Studenski S, Perera S, Patel K et al. Gait speed and survival in older adults. JAMA 2011;305:50–58.

22. Montero-Odasso M, Schapira M, Soriano ER et al. Gait velocity as a single predictor of adverse events in healthy seniors aged 75 years and older. J Gerontol A Biol Sci Med Sci 2005;60A:1304–1309.

23. Hausdorff JM. Gait variability: Methods, modeling and meaning. J Neuroeng Rehabil 2005;2:19.

24. Hausdorff JM. Gait dynamics, fractals and falls: Finding meaning in the stride-to-stride fluctuations of human walking. Hum Mov Sci 2007;26:555–589.

25. Montero-Odasso M, Muir SW, Hall M et al. Gait variability is associated with frailty in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 2011;66A:568–576.

26. Hausdorff JM, Cudkowicz ME, Firtion R et al. Gait variability and basal ganglia disorders: Stride-to-stride variations of gait cycle timing in Parkinson’s disease and Huntington’s disease. Mov Disord 1998;13:428–437.

27. Muir SW, Speechley M, Wells J et al. Gait assessment in mild cognitive

impairment and Alzheimer’s disease: The effect of dual-task challenges across the cognitive spectrum. Gait Posture 2011;35:96–100.

28. Brach JS, Studenski SA, Perera S et al. Gait variability and the risk of incident mobility disability in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 2007;62A:983–988.

29. Herman T, Giladi N, Gurevich T et al. Gait instability and fractal dynamics of older adults with a “cautious” gait: Why do certain older adults walk fearfully? Gait Posture 2005;21:178–185.

30. Hausdorff JM, Rios DA, Edelberg HK. Gait variability and fall risk in community-living older adults: A 1-year prospective study. Arch Phys Med Rehabil 2001;82:1050–1056.

31. Montero-Odasso M, Muir SW, Speechley M et al. Gait variability and mild cognitive impairment: The effect of increasing task complexity. Arch Phys Med Rehabil 2011;93:293–299.

32. Camicioli R, Majumdar SR. Relationship between mild cognitive impairment and falls in older people with and without Parkinson’s disease: 1-year prospective cohort study. Gait Posture 2010;32:87–91.

33. Oliver D, Connelly JB, Victor CR et al. Strategies to prevent falls and fractures in hospitals and care homes and effect of cognitive impairment: Systematic review and meta-analyses. BMJ 2007;334:82.

34. Hauer K, Becker C, Lindemann U et al. Effectiveness of physical training on motor performance and fall prevention in cognitively impaired older persons: A systematic review. Am J Phys Med Rehabil 2006;85:847–857.

35. Verghese J, Mahoney J, Ambrose AF et al. Effect of cognitive remediation on gait in sedentary seniors. J Gerontol A Biol Sci Med Sci 2010;65A:1338–1343.

36. Silsupadol P, Shumway-Cook A, Lugade V et al. Effects of single-task versus dual-task training on balance performance in older adults: A doubleblind, randomized controlled trial. Arch Phys Med Rehabil 2009;90: 381–387.

37. Schwenk M, Zieschang T, Oster P et al. Dual-task performances can be improved in patients with dementia: A randomized controlled trial. Neurology 2010;74:1961–1968.

38. Verghese J, Holtzer R. Walking the walk while talking: Cognitive therapy for mobility in dementia? Neurology 2010;74:1938–1939.

39. Mirelman A, Maidan I, Herman T et al. Virtual reality for gait training: Can it induce motor learning to enhance complex walking and reduce fall risk in patients with Parkinson’s disease? J Gerontol A Biol Sci Med Sci 2011;66A:234–240.

40. Auriel E, Hausdorff JM, Herman T et al. Effects of methylphenidate on cognitive function and gait in patients with Parkinson’s disease: A pilot study. Clin Neuropharmacol 2006;29:15–17.

41. Ben Itzhak R, Giladi N, Gruendlinger L et al. Can methylphenidate reduce fall risk in community-living older adults? A double-blind, single-dose cross-over study. J Am Geriatr Soc 2008;56:695–700.

42. Bohnen NI, Muller ML, Koeppe RA et al. History of falls in Parkinson disease is associated with reduced cholinergic activity. Neurology 2009;73:1670–1676.

43. Montero-Odasso M, Wells JL, Borrie MJ et al. Can cognitive enhancers reduce the risk of falls in older people with mild cognitive impairment? A protocol for a randomised controlled double blind trial BMC Neurol 2009;9:42.

44. Devos D, Defebvre L, Bordet R. Dopaminergic and non-dopaminergic pharmacological hypotheses for gait disorders in Parkinson’s disease. Fundam Clin Pharmacol 2010;24:407–421.

45. Drever BD, Riedel G, Platt B. The cholinergic system and hippocampal plasticity. Behav Brain Res 2011;221:505–514.

46. Assal F, Allali G, Kressig RW et al. Galantamine improves gait performance in patients with Alzheimer’s disease. J Am Geriatr Soc 2008;56:946–947.

47. Montero-Odasso M, Wells J, Borrie M. Can cognitive enhancers reduce the risk of falls in people with dementia? An open-label study with controls J Am Geriatr Soc 2009;57:359–360.

48. Chung KA, Lobb BM, Nutt JG et al. Effects of a central cholinesterase inhibitor on reducing falls in Parkinson disease. Neurology 2010;75: 1263–1269.

49. Beauchet O, Launay C, Fantino B et al. Does memantine improve the gait of individuals with Alzheimer’s disease? J Am Geriatr Soc 2011;59: 2181–2182.

50. Segev-Jacubovski O, Herman T, Yogev-Seligmann G et al. The interplay between gait, falls and cognition: Can cognitive therapy reduce fall risk? Expert Rev Neurother 2011;11:1057–1075.

51. www.v-time.ev Accessed October 14, 2012.

52. You JH, Shetty A, Jones T, Shields K, Belay Y, Brown D. Effects of dualtask cognitive-gait intervention on memory and gait dynamics in older adults with a history of falls: A preliminary investigation NeuroRehabilitation 2009;24:193–198.

Citation: Montero‐Odasso, M et al, 2012, “Gait and cognition: a complementary approach to understanding brain function and the risk of falling”, J Am Geriatr Soc 60:2127–2136.;jsessionid=91786DCB6222398186B7DF77BE291745.d01t02?deniedAccessCustomisedMessage=&userIsAuthenticated=false

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