Citrus flavonoids and lipid metabolism – Forum

Date: 2013-01-27

Reference number: OPUSeJ 201301272122CFL


to pre-reviewed version: N/A

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Title: Citrus flavonoids and lipid metabolism

Authors: Julia M Assini, Erin Mulvihill & Murray W. Huff

Moderator: N/A

Overview: N/A

Addendum: none

Erratum: none

Bibliography: (alphabetical) N/A


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26. Mulvihill EE, Allister EM, Sutherland BG, et al. Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance. Diabetes 2009; 58:2198–2210.

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47. Tsai SJ, Huang CS, Mong MC, et al. Anti-inflammatory and antifibrotic effects of naringenin in diabetic mice. J Agric Food Chem 2012; 60:514–521. This is the first study to show that treatment of diabetic mice with naringenin attenuates nephropathy through suppression of NF-kB-mediated renal inflammation.

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49. Lee CH, Jeong TS, Choi YK, et al. Antiatherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits. Biochem Biophys Res Commun 2001; 284:681–688.

50. Mulvihill EE, Assini JM, Sutherland BG, et al. Naringenin decreases progression of atherosclerosis by improving dyslipidemia in high-fat-fed low-density lipoprotein receptor-null mice. Arterioscler Thromb Vasc Biol 2010; 30: 742–748. Naringenin treatment of Ldlr-/- mice attenuated dyslipidemia and normalized hepatic lipid desposition and insulin resistance. This is the first study to show naringenin-induced inhibition of the progression of lesions to a more complex phenotype.

51. Chanet A, Milenkovic D, Deval C, et al. Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice. J Nutr Biochem 2012; 23:469–477. This is the first study to show that small doses of naringin fed to C57BL6 mice attenuate atherosclerosis, which is associated with differentially regulated aortic expression of genes encoding proteins involved in cell adhesion, actin cytoskeleton organization and cell division.

Citation: Assini, Julia M, Erin Mulvihill & Murray W. Huff, 2013, “Citrus flavonoids and lipid metabolism”, Current Opinion in Lipidology 24:1, 34–40. doi: 10.1097/MOL.0b013e32835c07fd

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