Date: 2013-01-27
Reference number: OPUSeJ 201301272122CFL
to pre-reviewed version: N/A
to cover page: http://www.opusej.org/library/citrus-flavonoids-and-lipid-metabolism-cover/
Title: Citrus flavonoids and lipid metabolism
Authors: Julia M Assini, Erin Mulvihill & Murray W. Huff
Moderator: N/A
Overview: N/A
Addendum: none
Erratum: none
Bibliography: (alphabetical) N/A
References:
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27. Mulvihill EE, Assini JM, Lee JK, et al. Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance. Diabetes 2011; 60:1446–1457. This is the first study to show that dietary nobiletin supplementation markedly attenuates atherosclerosis in mice. Nobiletin prevented hepatic steatosis, resulting normalization of hepatic insulin sensitivity, lipoprotein secretion and lipid deposition in peripheral tissues, including muscle, adipose tissue and the aortic sinus. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292317/
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29. Borradaile NM, de Dreu LE, Barrett PH, Huff MW. Inhibition of hepatocyte apoB secretion by naringenin: enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters. J Lipid Res 2002; 43:1544–1554. http://www.ncbi.nlm.nih.gov/pubmed/12235187
30. Goldwasser J, Cohen PY, Yang E, et al. Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha. PLoS One 2010; 5:e12399. http://www.plosone.org/article/info:doi/10.1371/journal.pone.0012399
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40. Milenkovic D, Deval C, Dubray C, et al. Hesperidin displays relevant role in the nutrigenomic effect of orange juice on blood leukocytes in human volunteers: a randomized controlled cross-over study. PloS One 2011; 6:e26669. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0026669
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42. Rizza S, Muniyappa R, Iantorno M, et al. Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J Clin Endocrinol Metab 2011; 96:E782–E792. This human study demonstrated that administration of the citrus flavonoid hesperidin treatment increased flow-mediated dilation and reduced concentrations of circulating inflammatory biomarkers (high-sensitivity C-reactive protein, serum amyloid A protein, soluble E-selectin). http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085197/
43. Ghanim H, Sia CL, Upadhyay M, et al. Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Am J Clin Nutr 2010; 91:940–949. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844681/
44. Soromou LW, Zhang Z, Li R, et al. Regulation of inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 murine macrophage by 7-Omethyl-naringenin. Molecules 2012; 17:3574–3585. http://europepmc.org/abstract/MED/22441335/reload=0;jsessionid=Ipvvn6p8ZzLtaamCiqfc.0
45. Miyata Y, Tanaka H, Shimada A, et al. Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin. Life Sci 2011; 88:613–618. http://www.ncbi.nlm.nih.gov/pubmed/21295043
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47. Tsai SJ, Huang CS, Mong MC, et al. Anti-inflammatory and antifibrotic effects of naringenin in diabetic mice. J Agric Food Chem 2012; 60:514–521. This is the first study to show that treatment of diabetic mice with naringenin attenuates nephropathy through suppression of NF-kB-mediated renal inflammation. http://www.ncbi.nlm.nih.gov/pubmed/22117528
48. Lee YS, Cha BY, Choi SS et al. Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice. J Nutr Biochem 2012 [Epub ahead of print]. http://www.ncbi.nlm.nih.gov/pubmed/22898571
49. Lee CH, Jeong TS, Choi YK, et al. Antiatherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits. Biochem Biophys Res Commun 2001; 284:681–688. http://www.ncbi.nlm.nih.gov/pubmed/11396955
50. Mulvihill EE, Assini JM, Sutherland BG, et al. Naringenin decreases progression of atherosclerosis by improving dyslipidemia in high-fat-fed low-density lipoprotein receptor-null mice. Arterioscler Thromb Vasc Biol 2010; 30: 742–748. Naringenin treatment of Ldlr-/- mice attenuated dyslipidemia and normalized hepatic lipid desposition and insulin resistance. This is the first study to show naringenin-induced inhibition of the progression of lesions to a more complex phenotype. http://atvb.ahajournals.org/content/30/4/742.full.pdf
51. Chanet A, Milenkovic D, Deval C, et al. Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice. J Nutr Biochem 2012; 23:469–477. This is the first study to show that small doses of naringin fed to C57BL6 mice attenuate atherosclerosis, which is associated with differentially regulated aortic expression of genes encoding proteins involved in cell adhesion, actin cytoskeleton organization and cell division. http://www.ncbi.nlm.nih.gov/pubmed/21684135
Citation: Assini, Julia M, Erin Mulvihill & Murray W. Huff, 2013, “Citrus flavonoids and lipid metabolism”, Current Opinion in Lipidology 24:1, 34–40. doi: 10.1097/MOL.0b013e32835c07fd http://journals.lww.com/co-lipidology/Abstract/2013/02000/Citrus_flavonoids_and_lipid_metabolism.7.aspx
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